Pharmacodynamic effects of subinhibitory concentrations of beta-lactam antibiotics in vitro
نویسندگان
چکیده
منابع مشابه
Pharmacodynamic effects of subinhibitory concentrations of beta-lactam antibiotics in vitro.
The pharmacodynamic effects of subinhibitory concentrations of different beta-lactam antibiotics were investigated. A postantibiotic effect (PAE) was induced for different bacterial species by exposure to 10x MIC of several beta-lactam antibiotics for 2 h in vitro. The antibiotic-bacterial combinations used in this study were imipenem-Pseudomonas aeruginosa, benzylpenicillin-Streptococcus pneum...
متن کاملThe Survey of Genes Encoding Beta-Lactamases, in Escherichia Coli Resistant to Beta-Lactam and Non-Beta-Lactam Antibiotics
Objective(s) Resistance to the new generation of cephalosporins which is mediated by Extended-Spectrum beta-lactamases (ESBLs) has been found among Escherichia coli isolates throughout the world. These resistance genes and their producers, the micro-organisms carrying beta-lactamases, are responsible for serious clinical and therapeutic problems among inpatients and it is necessary to pay more...
متن کاملBeta-Lactam Antibiotics and Vancomycin Beta-lactam antibiotics
Anti-bacterial drugs have “selective toxicity”, that is they interact with a target present on the bacterial cell, the prokaryote, that is not present in the mammalian host, the eukaryote. For the ß-lactam drugs, this target is the cell wall. Mammalian cells lack cell walls, which for the bacteria are a critically important barrier protecting the organism from not only the vagaries of osmotic s...
متن کاملIn vitro antagonism of beta-lactam antibiotics by cefoxitin.
We assessed the extent and mechanisms of antagonism of beta-lactam antibiotics by cefoxitin. In tests with 41 gram-negative isolates, cefoxitin antagonized cephalothin, cefamandole, cefsulodin, cefotaxime, moxalactam, ampicillin, carbenicillin, piperacillin, mezlocillin, and azlocillin, but not cephalexin, mecillinam, or N-formimidoyl thienamycin. The extent of antagonism varied with the beta-l...
متن کاملChemistry of Beta Lactam Antibiotics
Humans have been plagued with the threat of bacterial infection since before the dawn of recorded history, and have thus always had a keen interest in finding a suitable treatment for these maladies. In the early part of the 19th century, colonial Americans were fearful of death by bacterial infections that are now considered routine, and usually inquired about one another's health in their let...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1991
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.35.9.1834